Congenital bullous syphilis in a newborn: A novel approach to diagnosis using immunohistochemical staining on a blister roof.

We describe a rare presentation of congenital bullous syphilis in a premature neonate born with extensive skin desquamation. The newborn was noted to have diffuse erythema with widespread, superficial skin desquamation in addition to plantar bullae and erosions, and an absence of mucosal involvement. Immunohistochemical syphilis diagnostic staining was performed on a blister roof, highlighting a novel diagnostic approach for congenital bullous syphilis.

Psoriatic Presentation of Human Immunodeficiency Virus (HIV).

Human immunodeficiency virus (HIV) is a potentially life-threatening single-stranded RNA lentivirus that attacks the body's immune system by infecting CD4 T lymphocytes. If untreated, HIV infection can progress to acquired immunodeficiency syndrome (AIDS).1.2 With the US prevalence of around 12.6 per 100,000 individuals, HIV positivity remains undiagnosed among much of the population.3 The most common presentation of HIV includes flu-like manifestations, such as fever, malaise, diarrhea, weight loss, headache, and muscle aches; however, it is also known to present as other diseases, including psoriasis.1.

Diagnosis of Mycosis Fungoides after Dupilumab Treatment for Atopic Dermatitis.

A 46-year-old woman with a medical history of pseudoxanthoma elasticum presented with atopic dermatitis (AD) refractory to topical therapies (topical steroids, tacrolimus, and calcitriol), phototherapy, and excimer laser. Dupilumab was recommended, with resolution of most of her cutaneous infection.

Diagnosis and treatment of low-risk superficial basal cell carcinoma in a single visit.

INTRODUCTION: Surgical excision remains the most commonly utilized treatment for superficial basal cell carcinoma (sBCC). In the era of cost containment of healthcare, the rising incidence of BCC and the high cost of excision require a continuous search for efficient and cost-effective management. OBJECTIVE: Examine the feasibility of the diagnosis and treatment of low-risk sBCC in a single visit. MATERIALS AND METHODS: Retrospective chart review of sBCCs diagnosed and treated in a single visit. RESULTS: The study identified 151 histologically confirmed sBCCs in 86 patients over a 5-year period, 93 (61.6%) cases of which were diagnosed as low-risk sBCC and treated in a single appointment. The majority of the cases (n = 86) were treated with curettage alone and the rest (n = 7) with a shave removal technique. The average size of the lesion was 0.82 cm located primarily on the trunk and extremities (95.7%). One recurrence on the trunk was observed in the single appointment group. Overall, diagnostic sensitivity was 95.4% and specificity was 92.0%. CONCLUSIONS: Diagnosis and treatment of sBCC in a single visit is an efficient and cost-effective management option for those who are proficient in identifying low-risk sBCC.

Congenital onychodysplasia of the ring finger presenting as a bifid nail.

Congenital onychodysplasia, or Iso-Kikuchi syndrome, is classically defined as a congenital nail abnormality of one or both index fingers that is often associated with a bone abnormality in the affected finger. We report an unusual case of a 6-year-old girl who presented with an S-shaped, bifid nail of the left ring finger that had been present since birth. X-ray findings were used to confirm a diagnosis of congenital onychodysplasia of the ring finger.

Feasibility study of speech recognition for gathering information needs.

Automated speech recognition (ASR) is used in many areas of medicine today. However, not many studies have evaluated the usefulness of ASR applications for capturing clinician information needs in noisy environments. We evaluated 72 ASR transcribed clinician-generated questions and assessed them for semantic and syntactic errors. The results showed that basic user training is not sufficient in order to capture the semantics of recordings.